Gastroretentive sustained release formulations of Bergenia ciliata

US11446346B2 · kind B2 · utility

Assignee

• COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH · IN

Inventors

• Sonali Sandip Bharate · Jammu, IN
• Rohit Singh · Jersey City, US
• Mehak Gupta · Jammu, IN
• Bikarma Singh · Jammu, IN
• Anil Kumar Katare · Jammu, IN
• Ajay Kumar · Fairport, US
• Sandip Bibishan Bharate · Ranbir Singh Pura, IN
• Ram Vishwakarma · Jammu, IN

Key dates

• Filing date: Sep 11, 2018
• Grant date: Sep 20, 2022
• Expiry date: Sep 11, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/7034
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is related to a novel gastroretentive swellable oral dosage form for sustained or delayed release of bergenin, a active constituent of Bergenia ciliata extract/fraction and a process for preparing the same wherein the extract is wet-granulated using excipients i.e. biodegradable polymers and/or non-biodegradable polymers alone or in combination, and the said granules are either filled into a capsule or compressed into a tablet. The said formulation comprising a granulated extract of bergenin-rich Bergenia ciliata with polymers has resulted in a sustained release of extract in the stomach over a period of 16-24 hrs. The said formulations are useful for the treatment of inflammatory diseases.