Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
US11446365B2 · kind B2 · utility
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51References
13Claims
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Key dates
| Filing date | Aug 9, 2018 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | Aug 9, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.