Potent soft anti-inflammatory corticosteroid compounds and uses thereof
US11447522B2 · kind B2 · utility
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16Claims
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Key dates
| Filing date | Jun 13, 2018 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | Oct 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Potent soft corticosteroid pharmaceutical compositions comprising them and method for use as anti-inflammatory agents. Also, a method for softening fluticasone propionate and similar corticosteroids to arrive at potent but safer alternatives. The compound 5-fluoromethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate, which is equally potent to but safer than fluticasone, is among those provided. Another compound of particular interest is 2-hydroxyethyl 17α-dichloroacetoxy-6α,9α-difluoro-11β-hydroxy-16β-methyl-3-oxoandrosta-1,4-diene-17β-carboxylate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.