Binding unit targeting fibroblast activation protein α and application thereof

US11447570B2 · kind B2 · utility

Assignee

• CRAGE MEDICAL CO., LIMITED · CN

Inventors

• Zonghai LI · Shanghai, CN
• Peng Wang · Carlsbad, US

Key dates

• Filing date: Nov 16, 2018
• Grant date: Sep 20, 2022
• Expiry date: Nov 16, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A binding unit that specifically binds to fibroblast activation protein α (FAPα), a polynucleotide that encodes the binding unit, a vector that comprises the polynucleotide and a host cell, a method for use in producing the antigen-binding unit and a method for treating a disease by using the FAPα-specific binding unit; the binding unit that specifically binds to FAPα may efficiently bind to tumor cells that express FAPα, and immune effector cells comprising the binding unit exhibit significant killing capabilities against tumor cells that express FAP.