Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
US11447807B2 · kind B2 · utility
8Cited by
60References
22Claims
0Family size
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Key dates
| Filing date | Feb 28, 2019 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | Dec 16, 2039 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0636
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.