ChemFET sensor array including overlying array of wells

US11448613B2 · kind B2 · utility

Assignee

• Life Technologies Corporation · US

Inventors

• Jonathan M. Rothberg · Paradise, US
• Wolfgang Hinz · Killingworth, US
• John F. Davidson · Guilford, US
• Antoine M. van Oijen · Needham, US
• John Leamon · Norwick, GB
• Martin Huber · Uttenreuth, DE
• Mark Milgrew · Branford, US
• James Bustillo · Castro Valley, US

Key dates

• Filing date: Aug 10, 2018
• Grant date: Sep 20, 2022
• Expiry date: Mar 25, 2039

Classification

• Technology area (CPC H): Electricity
• CPC primary: H10D84/01
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.