Methods to specifically profile protease activity at lymph nodes

US11448643B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Sangeeta N. Bhatia · Lexington, US
• Darrell J. Irvine · Arlington, US
• Karl Dane Wittrup · Urbana, US
• Andrew David Warren · Cambridge, US
• Jaideep S. Dudani · Boston, US
• Naveen Mehta · Cambridge, US

Key dates

• Filing date: Apr 7, 2017
• Grant date: Sep 20, 2022
• Expiry date: Apr 7, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/96425
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of pro teases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions (e.g., metastatic cancer, infection with certain pathogenic agents).