Method for identifying a modulator of the TNFα or CD40L interaction with their cognate receptors
US11448655B2 · kind B2 · utility
1Cited by
13References
17Claims
0Family size
Assignee
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Key dates
| Filing date | May 26, 2020 |
| Grant date | Sep 20, 2022 |
| Priority date | — |
| Expiry date | May 26, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.