Method for synthesizing a new ferrihydrite nano-photosensitizer and its antibacterial and anticancer use
US11452777B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Dec 20, 2019 |
| Grant date | Sep 27, 2022 |
| Priority date | — |
| Expiry date | Feb 13, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a method for synthesizing a new ferrihydrite nano-photosensitizer, comprising steps of: weighing 303 mg of Fe(NO3)3⋅9H2O solid dissolved fully in 30 ml of distilled water to prepare a 0.75 mM of Fe(NO3)3 solution in water; adding PEG solid to the solution in water by stirring to fully dissolve at a molar ratio of PEG to Fe3+ of 1:1-1:50; stirring the obtained solution under heating at 75° C. in a water bath for 10-50 minutes, and then immediately cooling in an ice bath after removing; centrifuging and washing the cooled mixed solution at high speed under low temperature with the supernatant discarded, to obtain pellets as PEG-modified ferrihydrite nanoparticles (PEG-Fns). The PEG-Fns synthesized in the present invention can be controllably induced and reduced by blue light to release Fe2+, and then produce ⋅OH through Fenton reaction of Fe2+ and H2O2 in the cell, which induces cell oxidative damage, thereby achieving controllable anticancer and antibacterial purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.