Tissue stain and use thereof
US11452783B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 29, 2017 |
| Grant date | Sep 27, 2022 |
| Priority date | — |
| Expiry date | Aug 29, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2090/395
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a tissue staining composition containing carbon particles having a mean particle diameter less than 0.3 μm in diameter (optionally less than 0.2 μm in diameter) together with one or more agents that maintain the carbon particles in suspension (for example, an anti-settling agent and/or surfactant). In certain circumstances, the anti-settling agent may also have mucoadhesive properties. The tissue staining composition is visually dark and does not disperse rapidly when introduced into regions of tissue of interest making it ideal for marking the regions that can be visualized clearly and over prolonged periods of time via, for example, direct visualization, endoscopic or laparoscopic inspection. The invention also provides methods of making and using the tissue staining composition for marking regions of tissue of interest, for example, gastrointestinal tissue, as well as other tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.