Methods and systems for performing chromatographic alignment
US11454617B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 2019 |
| Grant date | Sep 27, 2022 |
| Priority date | — |
| Expiry date | Jul 30, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/8648
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An exemplary chromatographic alignment system accesses a target file including data representative of a plurality of chromatographic features detected from a first sample and a reference file including data representative of a plurality of chromatographic features detected from a second sample. The system identifies, based on the target and reference files, a distinct retention time offset value for each chromatographic feature included in a first subset of the plurality of chromatographic features detected from the first sample. The system determines, based on the identified distinct retention time offset values for the chromatographic features included in the first subset and on a machine learning model, a distinct predicted retention time offset value for each chromatographic feature included in a second subset of the plurality of chromatographic features detected from the first sample. The system assigns the distinct predicted retention time offset value for each chromatographic feature included in the second subset.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.