Lyophilization of RNA

US11458100B2 · kind B2 · utility

Assignee

• CureVac Manufacturing GmbH · DE

Inventors

• Thomas Ketterer · Bingen, DE
• Thorsten MUTZKE · Reutlingen, DE
• Michael Wiggenhorn · Munich, DE
• Frank Schaubhut · Germering, DE
• Florian Von Der Mülbe · Stuttgart, DE

Key dates

• Filing date: Dec 5, 2021
• Grant date: Oct 4, 2022
• Expiry date: Dec 5, 2041

Classification

• Technology area (CPC —): General

Abstract

The present invention is directed to the field of RNA formulation, in particular to lyophilization of RNA. The invention provides a method for lyophilization of RNA. The present invention further concerns a lyophilized composition obtainable by the inventive method, a pharmaceutical composition, a vaccine and a kit or kit of parts. Moreover, the present invention provides a novel use of a lyoprotectant for lyophilizing RNA, the use of the inventive method in the manufacture of a medicament as well as the first and second medical use of the composition obtainable by the inventive method, the pharmaceutical composition, the vaccine or the kit or kit of parts according to the invention.