Targeted conjugates and particles and formulations thereof

US11458206B2 · kind B2 · utility

Assignee

• TVA (ABC), LLC · US

Inventors

• Rossitza G. Alargova · Watertown, US
• Mark T. Bilodeau · Waltham, US
• Craig A. Dunbar · Needham, US
• Sudhakar Kadiyala · Newton, US
• Rajesh R. Shinde · Waltham, US
• Patrick Lim Soo · Ridgewood, US
• Beata Sweryda-Krawiec · Marlborough, US
• Brian H. White · Malden, US
• Patrick Rosaire Bazinet · Somerville, US
• Richard Wooster · Natick, US

Key dates

• Filing date: Feb 18, 2020
• Grant date: Oct 4, 2022
• Expiry date: Feb 18, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.