Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene
US11459293B2 · kind B2 · utility
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14Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 26, 2018 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Oct 26, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/999
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula Iwhich are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.