Sulphur substituted 3-oxo-2,3-dihydropyridazine-4-carboxamides

US11459312B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE
• Deutsches Krebsforschungszentrum · DE

Inventors

• Ludwig Zorn · Berlin, DE
• Ulrike Röhn · Berlin, DE
• Ilona GUTCHER · Berlin, DE
• Lars Röse · Berlin, DE
• Benjamin Bader · Berlin, DE
• Christina KOBER · Lollar, DE
• Rafael CARRETERO · Heidelberg, DE
• Detlef STÖCKIGT · Potsdam, DE
• Michael Platten · Heidelberg, DE

Key dates

• Filing date: Nov 16, 2018
• Grant date: Oct 4, 2022
• Expiry date: Nov 16, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of general formula (I): wherein R1, R2, A, X, Y and Z are as defined herein, methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.