Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and use thereof
US11459327B1 · kind B1 · utility
4Cited by
1References
6Claims
0Family size
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Key dates
| Filing date | Jun 7, 2021 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Jun 9, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cycloalkyl and hetero-cycloalkyl inhibitors, preparation methods therefor, and the use thereof are described. Compounds of the present invention have a structure represented by formula (I). Further disclosed are preparation methods for said compounds, and the use of said compounds as KRASG12C inhibitors. The compounds have an excellent ability to selectively inhibit KRASG12C, improved pharmacodynamic and pharmacokinetic performance, and reduced toxic side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.