N/O-linked Degrons and Degronimers for protein degradation
US11459335B2 · kind B2 · utility
4Cited by
10References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2019 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Jan 19, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG07F17/3288
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.