Process for purifying liraglutide
US11459354B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Mar 25, 2020 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Sep 10, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/605
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides improved processes for purifying liraglutide. Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchange step, where a pH is kept constant in the first and second purification steps. In particular, the processes utilize a halogenated solvent in a sample preparation step, which provides better solubility and an environment suitable for decarboxylation for crude liraglutide prior to a RP-HPLC purification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.