Anti-VEGF protein compositions and methods for producing the same
US11459373B2 · kind B2 · utility
5Cited by
72References
16Claims
0Family size
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Key dates
| Filing date | Oct 13, 2021 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Oct 13, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure pertains to compositions comprising aflibercept and methods for producing such compositions in chemically defined media and using anion exchange chromatography to produce aflibercept with a specific glycosylation profile. In particular, these methods produce aflibercept with a glycosylation profile with specific ranges of % total fucosylated glycans, total sialylated glycans, mannose-5, and galactosylated glycans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.