Methods of preparing a solid composition containing proteases

US11459556B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Werner Hoelke · Penzberg, DE
• Michaela Fischer · Wolfratshausen, DE
• Johann-Peter Thalhofer · Weilheim, DE
• Markus Weber · Langenfeld, DE

Key dates

• Filing date: May 4, 2020
• Grant date: Oct 4, 2022
• Expiry date: May 4, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/24027
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.