Compositions and methods for improving sample identification in indexed nucleic acid libraries
US11459610B2 · kind B2 · utility
0Cited by
8References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 23, 2018 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Feb 10, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B80/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is concerned with compositions and methods for improving the rate of correct sample identification in indexed nucleic acid library preparations for multiplex next generation sequencing by exonuclease treatment and optionally blocking the 3′ ends of pooled indexed polynucleotides from multiple samples prior to amplification and sequencing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.