Method for monitoring, evaluating, and controlling a cyclic chromatographic purification process
US11460454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2018 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | Oct 2, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/6034
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for monitoring, evaluating and controlling a cyclic chromatographic purification process that involves at least two adsorbers. According to the method, one step is monitoring of the chromatogram, including the measurement of at least one current concentration-proportional signal in the liquid. Another step is conducting an evaluation of the chromatogram, including a comparison of at least one of the current concentration-proportional signals measured in the monitoring step with a threshold value thereof. A further step is controlling the chromatographic purification process by adapting the termination of the currently running phase as a function of the comparison of the evaluation step and initiating the next phase. Finally, according to the method, the sequence of steps is carried out in given order at least twice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.