Identifying presence and composition of cell-free nucleic acids
US11462296B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 2017 |
| Grant date | Oct 4, 2022 |
| Priority date | — |
| Expiry date | May 4, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B40/08
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal. These cell-free nucleic acids that are identified can be used as biomarkers to determine the presence of a disease, its biological behavior, its rate of progression, and/or the response of the disease to one or more unique therapies. In other examples, the cell-free nucleic acids may be used as biomarkers to determine a response of the host species to the tissue of the donor organism or a response of tissue derived from the second organism to transplantation within the first organism of the first species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.