Method of making a personalized bone graft

US11464640B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Gordana Vunjak-Novakovic · New York, US
• Warren Grayson · Reisterstown, US
• Keith Yeager · Jersey City, US

Key dates

• Filing date: Dec 18, 2019
• Grant date: Oct 11, 2022
• Expiry date: Sep 27, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2002/30957
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.