Particles for targeted delivery and uses in managing bleeding or blood clotting

US11464748B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• Children's Healthcare of Atlanta · US
• Georgia Tech Research Corporation · US
• Chapman University · US

Inventors

• Wilbur Lam · Decatur, US
• Caroline Hansen · Atlanta, US
• Yumiko Sakurai · Atlanta, US
• Andrew Lyon · Carmel Farms, US

Key dates

• Filing date: Jan 31, 2017
• Grant date: Oct 11, 2022
• Expiry date: Sep 19, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to microcapsule particles for targeted delivery of drugs. In certain embodiments, the particles comprise polyelectrolyte polymers, e.g., layers of anionic polymers and cationic polymers. In certain embodiments, the particles have a fibrinogen coating. In certain embodiments, the particles contain a polysaccharide core and/or a polysaccharide coating encapsulating drugs, proteins, clotting agents, coagulation factors, or anticoagulants. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of or duration of bleeding. In certain embodiments, this disclosure contemplates methods of using particles disclosed herein to prevent or reduce onset of blood clotting.