Pyruvate kinase modulators and use thereof

US11464775B2 · kind B2 · utility

Assignee

• Agios Pharmaceuticals, Inc. · US

Inventors

• Giovanni Cianchetta · Waltham, US
• Charles Kung · Arlington, US
• Tao Liu · Shanghai, CN
• Anil Kumar Padyana · Oxford, US
• Zhihua Sui · Flemington, US
• Zhenwei Cai · Skillman, US
• Dawei Cui · Shanghai, CN
• Jingjing Ji · Shanghai, CN

Key dates

• Filing date: Aug 15, 2018
• Grant date: Oct 11, 2022
• Expiry date: Nov 9, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.