Anthranilic amides and the use thereof

US11465978B2 · kind B2 · utility

Assignees

• The Administrators of the Tulane Educational Fund · US
• DUQUESNE UNIVERSITY OF THE HOLY GHOST · US

Inventors

• Suravi Chakrabarty · Pittsburgh, US
• Patrick T. Flaherty · Pittsburgh, US
• Darlene Monlish · Clayton, US
• Jane E. Cavanaugh · Pittsburgh, US
• Matthew E. Burow · New Orleans, US
• Steven G. Elliott · Newbury Park, US
• Van T. HOANG · New Orleans, US

Key dates

• Filing date: Sep 11, 2014
• Grant date: Oct 11, 2022
• Expiry date: Sep 11, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.