Bicylic compound acting as an inhibitor

US11466024B2 · kind B2 · utility

Assignees

• Chia Tai Tianqing Pharmaceutical Group Co., Ltd. · CN
• Medshine Discovery Inc. · CN

Inventors

• Kevin X. Chen · Edison, US
• Kai ZHOU · Shanghai, CN
• Yanxin YU · Shanghai, CN
• Boyu HU · Lianyungang, CN
• Linghui Wu · Shanghai, CN
• Xiaoyuan Chen · Acton, US
• Jiangfeng LIN · Lianyungang, CN
• Haomin CHEN · Lianyungang, CN
• Xiangjian Wang · 安丰镇, CN
• Xiquan Zhang · 安丰镇, CN
• Xin Tian · 安丰镇, CN
• Hongjiang Xu · Lianyungang, CN

Key dates

• Filing date: Jul 27, 2018
• Grant date: Oct 11, 2022
• Expiry date: Jul 27, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A bicyclic compound acting as a RORγ inhibitor. Provided are a compound of formula (I) or a pharmaceutically acceptable salt thereof, the compound having a structure as represented by formula (I-A) or formula (I-B). The provided compound of formula (I-A) or formula (I-B) or pharmaceutically acceptable salt thereof has good RORγ inhibitory activities, being expected to be used for treating diseases mediated by RORγ receptors in a mammal.