Process for preparing methyl phosphinic acid butyl ester

US11466041B2 · kind B2 · utility

Assignee

• ADAMA AGAN LTD. · IL

Inventors

• Avihai Yacovan · Mazkeret Batya, IL
• Alexander Shterenberg · Rehovot, IL
• Leonid Erchov · Bet Shemesh, IL
• Sveta Fronton · Lod, IL
• Gerd-Volker Roeschenthaler · Bremen, DE
• Mykhailo Shevchuk · Bremen, DE
• Olesya Stubbmann-Kazakova · Bassum, DE
• Nataliya Kalinovich · Bremen, DE

Key dates

• Filing date: Feb 16, 2018
• Grant date: Oct 11, 2022
• Expiry date: Feb 16, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/3211
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present subject matter provides a safe alternative for producing an important intermediate useful for preparing the herbicide glufosinate, without need for chlorine components in the manufacturing process. In particular, a process for preparing alkyl phosphinic aid alkyl ester is provided, including the step of alkylating alkyl phosphinic acid ester in a non-polar solvent in the same apparatus as used to first produce the alkyl phosphinic acid ester, and without isolating the alkyl phosphinic acid ester before the alkylation step is conducted. More specifically, a process is presented for preparing methyl phosphinic acid butyl ester, by alkylating butyl phosphinic acid ester in a non-polar solvent, in the same apparatus as used previously to first produce the butyl phosphinic acid ester and without isolating the butylphosphinic acid ester before alkylation.