Polypeptide and use thereof

US11466053B2 · kind B2 · utility

Assignee

• BGI SHENZHEN · CN

Inventors

• Yunxia Tang · Lo Wu, CN
• Bo Li · San Jose, US
• Yong Hou · Tangxia, CN
• Shuntao Luo · Tangxia, CN
• Ying Huang · Lo Wu, CN
• Geng Liu · Longbeilingcun, CN
• Dongli Li · Longbeilingcun, CN
• Xiumei Lin · Lo Wu, CN

Key dates

• Filing date: May 20, 2019
• Grant date: Oct 11, 2022
• Expiry date: May 7, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70539
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a polypeptide and nucleic acid for encoding the polypeptide, a nucleic-acid construct, an expression vector, and a host cell containing the nucleic acid, an antigen-presenting cell presenting the polypeptide on the surface of the cell, and immune effector cell thereof, a pharmaceutical composition containing the polypeptide, a vaccine containing the nucleic acid, the nucleic acid construct, the expression vector, the host cell, the antigen-presenting cell, and the immune effector cell, and an antibody recognizing the polypeptide. Also provided is a therapeutic method using the polypeptide, the nucleic acid, the pharmaceutical composition, the vaccine, and the antibody. Also provided are a diagnosis method and diagnosis apparatus for detecting the described polypeptide. Also provided is an application of the polypeptide in preparing a vaccine, a tumor diagnosis kit, or a pharmaceutical composition, and an application of the polypeptide or the nucleic acid as a test target in tumor diagnosis.