Anti-PD-1 antibodies and methods of making and using thereof

US11466084B2 · kind B2 · utility

Assignee

• SystImmune, Inc. · US

Inventors

• Brian R. Kovacevich · Snohomish, US
• Dong Xia · Redmond, US
• Anne Elisabeth Carvalho Jensen · San Francisco, US
• Jonathan K. Fallen · Quincy, US
• Blair R. Renshaw · Renton, US
• Jeffrey B. Adamo · Bellevue, US
• Phil Tan · Edmonds, US
• Zeren Gao · Redmond, US
• Yi Zhu · Chengdu, CN

Key dates

• Filing date: Jun 22, 2018
• Grant date: Oct 11, 2022
• Expiry date: Jun 22, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The application provides anti-PD-1 monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.