Patent · US Active

Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof

US11466290B2 · kind B2 · utility

1Cited by

0References

12Claims

0Family size

Assignee

Cedars Sinai Medical Center · US

Inventors

Joshua Breunig · Los Angeles, US
Moise Danielpour · Los Angeles, US
Gi Bum Kim · Seojong-myeon, KR

Key dates

Filing date	Dec 30, 2016
Grant date	Oct 11, 2022
Priority date	—
Expiry date	Nov 3, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/50
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Described herein are donor vectors and systems for use in in vivo dual recombinase-mediated cassette exchange. Also described are animal models for consistent, rigorous, and facile investigation of transgene expression. Further described are methods of screening for therapeutic drugs using these animal models, and methods of treatment.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.