Autophagy modulators for use in treating cancer

US11471460B2 · kind B2 · utility

Assignee

• THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · US

Inventors

• Melvin L. DePamphilis · Olney, US
• Gaurav Sharma · Webster, US
• Juan Jose Marugan · Gaithersburg, US
• Marc Ferrer · Potomac, US
• Ajit Roy · Bengaluru, IN

Key dates

• Filing date: May 26, 2020
• Grant date: Oct 18, 2022
• Expiry date: Nov 21, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.