Methods and compositions for stimulating immune response

US11471522B2 · kind B2 · utility

Assignees

• BIONTECH SE · DE
• TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Mahjoub Bihi · Mainz, DE
• Ugur Sahin · Mainz, DE
• Mustafa Diken · Mainz, DE
• Thorsten Klamp · Mainz, DE

Key dates

• Filing date: Mar 21, 2018
• Grant date: Oct 18, 2022
• Expiry date: Jul 14, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2760/16134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods and compositions for stimulating an immune response. In particular, the present invention relates to immunostimulatory RNA molecules comprising sequences derived from an Influenza A virus nucleoprotein-encoding RNA molecule that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.