Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
US11472767B2 · kind B2 · utility
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Key dates
| Filing date | Aug 2, 2019 |
| Grant date | Oct 18, 2022 |
| Priority date | — |
| Expiry date | Aug 2, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/69
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.