Methods and compositions for promoting immune cell function

US11472856B2 · kind B2 · utility

Assignee

• Torque Therapeutics, Inc. · US

Inventors

• Ferdinando Pucci · Quincy, US
• Thomas Lars Andresen
• Douglas Jones · Newton, US
• Ulrik Nielsen · Quincy, US
• James A. Rakestraw · Cambridge, US

Key dates

• Filing date: Jun 13, 2017
• Grant date: Oct 18, 2022
• Expiry date: Jun 10, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure features, at least in part, methods for conserving cell function, e.g., immune cell function, e.g., after one or more cycles of freezing and/or thawing the nucleated cell. In embodiments, the methods comprise contacting an immune cell with a protein nanoparticle comprising an IL-15 complex.