Compositions and methods for directing proteins to specific loci in the genome
US11473082B2 · kind B2 · utility
0Cited by
43References
28Claims
0Family size
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Key dates
| Filing date | Jun 16, 2016 |
| Grant date | Oct 18, 2022 |
| Priority date | — |
| Expiry date | Nov 2, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are compositions and methods for directing proteins to specific loci in the genome and uses thereof. In one aspect, the disclosed methods allow for directing proteins to specific loci in the genome of an organism, including the steps of providing a fusion protein comprising a DNA localization component and an effector molecule. Preferred embodiments of the disclosure include, but are not limited to, the following fusion proteins: dSaCas9-Clo051, dCas9-Clo051, Xanthomonas-TALE-Clo051, and Ralstonia-TALE-Clo051.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.