Drug target for preventing pathologic calcium overload in cardiomyocytes and methods of screening for same

US11474098B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• THE NEW YORK PRESBYTERIAN HOSPITAL · US

Inventors

• Steven Marx · New York, US
• Alexander Kushnir · Passaic, US
• Lin Yang · 安丰镇, CN
• Alex Katchman · New York, US
• Henry M. Colecraft · Pages Corner, US

Key dates

• Filing date: Dec 20, 2018
• Grant date: Oct 18, 2022
• Expiry date: Sep 15, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides, inter alia, methods for identifying a candidate agent that can treat or ameliorate the effects of a heart condition caused by the effects of abnormal beta-adrenergic receptor activation on calcium levels in cardiomyocytes in a subject. Compositions that include the candidate agents identified by the methods disclosed, and methods of treating or ameliorating the effects of a heart condition in a subject by administering to the subject the candidate agents identified by the methods disclosed, are also provided.