Patent · US Active

Compositions and methods for inhibiting phenyl triazole MLL1-WDR5 protein-protein interaction

US11479545B2 · kind B2 · utility

1Cited by

3References

10Claims

0Family size

Assignee

CHINA PHARMACEUTICAL UNIVERSITY · CN

Inventors

Qidong You · 安丰镇, CN
Xiaoke GUO · 安丰镇, CN
Dongdong Li · Canton, US
Weilin Chen · 安丰镇, CN
Zhihui Wang · Beijing, CN

Key dates

Filing date	Oct 22, 2020
Grant date	Oct 25, 2022
Priority date	—
Expiry date	Oct 22, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present disclosure relates to the field of medicinal chemistry, in particular to a phenyl triazole MLL1-WDR5 protein-protein interaction inhibitor (I) and a preparation method thereof, and pharmacodynamics experiments prove that the compound of the present disclosure has relatively strong MLL1-WDR5 protein-protein interaction inhibition activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.