Ifosfamide intermediate, preparation method and application thereof
US11479572B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Oct 2, 2021 |
| Grant date | Oct 25, 2022 |
| Priority date | — |
| Expiry date | Oct 2, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/222
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention discloses an ifosfamide intermediate, a preparation method and application thereof. The ifosfamide intermediate has formula I. The ifosfamide intermediate reacts with a chlorinating agent, and then cyclization is performed under the action of an organic base to obtain ifosfamide. Compared with the existing synthetic routes, the method of the invention has the advantages that the use of highly toxic and explosive ethyleneimine can be avoided, and the use of explosive chemicals can be avoided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.