Methods and compositions for determining ploidy
US11479812B2 · kind B2 · utility
1Cited by
148References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 10, 2016 |
| Grant date | Oct 25, 2022 |
| Priority date | — |
| Expiry date | Dec 24, 2038 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. for detecting cancer or a chromosomal abnormality in a gestating fetus. The methods can utilize a set of more than 200 SNPs that are found within haploblocks and can include analyzing a series of target chromosomal regions related to cancer or a chromosomal abnormality in a gestating fetus. Finally the method may use knowledge about chromosome crossover locations or a best fit algorithm for the analysis. The compositions may comprise more than 200 primers located within haplotype blocks known to show CNV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.