Delivery of aerosolized respiratory pathogens

US11480560B2 · kind B2 · utility

Assignee

• The Regents of the University of Colorado, a Body Corporate · US

Inventors

• Kambez Hajipouran Benam · Denver, US
• Brian Frazier Niemeyer · Denver, US
• Alexander Kaiser · Neutraubling, DE

Key dates

• Filing date: Jun 11, 2019
• Grant date: Oct 25, 2022
• Expiry date: Nov 10, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/56983
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A system comprising a respirator, a biochip, and an atomizer for studying respiratory pathogens. The respirator of the system is configured to create breathe-mimicking air movement, the biochip comprises an airway lumen in fluid communication with the respirator, and the atomizer is in fluid communication with the airway lumen of the biochip, according to various embodiments. The atomizer may be configured to generate droplets of a respiratory pathogen (e.g., from liquid inoculum). In various embodiments, the breath-mimicking air movement comprises air volume as a function of time, wherein the respirator is configured to generate breathing cycles.