Compositions and methods comprising bone morphogenetic protein and NEMO binding peptide

US11484575B2 · kind B2 · utility

Assignees

• Cedars Sinai Medical Center · US
• Warsaw Orthopedic, Inc.

Inventors

• Juliane Glaeser · Los Angeles, US
• Hyun Joo BAE · Los Angeles, US
• Linda Kanim · Los Angeles, US
• Dmitriy Sheyn · Los Angeles, US
• Khosrowdad Salehi · Los Angeles, US

Key dates

• Filing date: Dec 19, 2019
• Grant date: Nov 1, 2022
• Expiry date: Mar 11, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An osteogenic composition for implantation at or near a target tissue site beneath the skin is provided, the osteogenic composition comprising bone morphogenetic protein and a NEMO binding domain peptide, where the NEMO binding domain peptide reduces soft tissue inflammation at or near the target tissue site. In some embodiments, a method is provided for treating a target tissue site in a patient in need of such treatment, the method comprising implanting an osteogenic composition comprising bone morphogenetic protein and a NEMO binding domain peptide, where the NEMO binding domain peptide reduces soft tissue inflammation at or near the target tissue site.