Methods of promoting corticospinal neuronal outgrowth in neuronal lesions using a pro-regenerative human osteopontin fragment

US11484576B2 · kind B2 · utility

Assignees

• Children's Medical Center Corporation · US
• President and Fellows of Harvard College · US

Inventors

• Joshua Sanes · Chesterfield, US
• Xin Duan · Somerville, US
• Mu Qiao · Belmont, US
• Zhigang He · Wellesley, US
• Fengfeng Bei · Boston, US
• Yuanyuan Liu · Shanghai, CN

Key dates

• Filing date: Aug 13, 2018
• Grant date: Nov 1, 2022
• Expiry date: Aug 13, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods for promoting neuronal outgrowth in a subject with a neuronal lesion in their CNS by administering effective amounts of a pro-regenerative OPN fragment, optionally with IGF1 and/or BDNF. A voltage gated potassium channel blocker can also be administered. Pharmaceutical compositions, devices for administration, and kits are also disclosed.