Intermediate drug with synergistic anticancer activity and polyethylene glycol-coupled synergistic anticancer drug, and preparation method therefor and use thereof

US11484600B2 · kind B2 · utility

Assignee

• CHONGQING UPGRA BIOTECHNOLOGY CO., LTD. · CN

Inventors

• Gaoquan Li · Park City, US
• Bin Wang · Beijing, CN
• Dajun Li · Qingdao, CN
• Qian Zhang · Shanghai, CN
• Lei Huang · Duluth, US
• Maofen Chen · Chongqing, CN
• Xiaodan Wu · Chongqing, CN
• Liangyan Peng · Chongqing, CN
• Tingting He · Chongqing, CN
• Yanyan Zhang · Lo Wu, CN
• Yun TANG · Cambridge, US
• Huan Liu · Beijing, CN
• Jvyuan Shui · Chongqing, CN
• Cuifang Zhang · Beijing, CN
• Jianhuan LI · Chongqing, CN

Key dates

• Filing date: Jan 22, 2018
• Grant date: Nov 1, 2022
• Expiry date: Jan 22, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are an intermediate drug having synergistic anticancer activity and a polyethylene glycol-coupled synergistic anticancer drug, and a method preparing therefor and use thereof. The intermediate drug has the general structural formula of (I), and the polyethylene glycol-coupled synergistic anticancer drug has the general structural formula of (II). The drugs achieve the combined medication of various anticancer drugs and avoid the toxic reaction caused by the interaction among the drugs or by the pharmacokinetics of the drugs when taking various anticancer drugs, facilitate overcoming the multidrug resistance of cancers, have a synergistic effect, and can be used for preparing anticancer medicaments and for treating cancers.