Stem cells and devices for bone regeneration

US11484625B2 · kind B2 · utility

Assignee

• ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA · US

Inventors

• Yang Chai · Pasadena, US
• Yong Chen · 林湖乡, CN
• Yuan Yuan · Sunnyvale, US
• Yuxing Guo · Qinhuangdao City, CN
• Xiangjia Li · Los Angeles, US
• Zoe Johnson · Los Angeles, US

Key dates

• Filing date: Nov 8, 2018
• Grant date: Nov 1, 2022
• Expiry date: Feb 9, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L67/04
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.