Compounds for treatment of PD-L1 diseases

US11485708B2 · kind B2 · utility

Assignee

• CHEMOCENTRYX, INC. · US

Inventors

• Viengkham Malathong · Mountain View, US
• Pingchen Fan · Fremont, US
• Christopher W. Lange · Hayward, US
• Venkat Reddy Mali · Cupertino, US
• Darren McMurtrie · Daly City, US
• Sreenivas Punna · Sunnyvale, US
• Howard S. Roth · Champaign, US
• Rajinder Singh · Belmont, US
• Ju Yang · Palo Alto, US
• Penglie Zhang · Foster City, US

Key dates

• Filing date: Jun 19, 2020
• Grant date: Nov 1, 2022
• Expiry date: Jun 19, 2040

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and the subscript n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.