Inhibitors of TRPC6

US11485740B2 · kind B2 · utility

Assignees

• Boehringer Ingelheim International GmbH · DE
• Hydra Biosciences, LLC · US

Inventors

• Steven Richard Brunette · Ridgefield, US
• Jianwen CUI · Ridgefield, US
• Michael Dennis Lowe · White Plains, US
• Christopher Ronald Sarko · San Ramon, US
• Simon Surprenant · Boisbriand, CA
• Michael Robert Turner · Danbury, US
• Xinyuan Wu · Newton, US
• Lana Louise Smith Keenan · Poughquag, US
• Thierry Bouyssou · Mietingen, DE
• Paul Leslie Nicklin · Ingelheim am Rhein, DE

Key dates

• Filing date: Feb 13, 2019
• Grant date: Nov 1, 2022
• Expiry date: Oct 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts therefore, wherein R1 to R6, A, U, V, W, X, Y, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.