High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds

US11485744B2 · kind B2 · utility

Assignee

• Techfields Pharma Co., Ltd. · CN

Inventors

• Chongxi Yu · Kensington, US
• Lina Xu · Beijing, CN
• Yuhua Chen · Shanghai, CN
• Binbing Yan · Shanghai, CN
• Shiqian Tu · Shanghai, CN

Key dates

• Filing date: Apr 9, 2018
• Grant date: Nov 1, 2022
• Expiry date: Apr 9, 2038

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.