Apramycin derivatives
US11485751B2 · kind B2 · utility
0Cited by
2References
14Claims
0Family size
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Inventors
Key dates
| Filing date | May 1, 2018 |
| Grant date | Nov 1, 2022 |
| Priority date | — |
| Expiry date | Oct 15, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/232
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.